Aromatic carbohydrate amphiphile disrupts cancer spheroids and prevents relapse
Abstract
Phosphorylated carbohydrate amphiphile acts as a potent antimetabolite due to glycolysis inhibition and in situ formation of supramolecular net. Its efficiency is higher in spheroids as compared to the conventional 2D cultures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2020
- Source ID
- 10.1039/d0nr05008c
Entities
People
- Alexandra Brito
- Iva Pashkuleva
- Jason S. Lewis
- Patrícia M R Pereira
- Rein V Ulijn
- Ricardo A. Pires
- Rui L. Reis
Organizations
- Army Research Office
- CUNY Graduate School and University Center
- City University of New York
- Fundação para a Ciência e Tecnologia
- Horizon 2020
- Memorial Sloan Kettering Cancer Center
- National Institutes of Health
- National Science Foundation
- United States Army
- United States Army Research Laboratory
- University of Minho
- Weill Cornell Medicine
- Yusuf Hamied Department of Chemistry