Small molecules targeting the NEDD8·NAE protein–protein interaction

Abstract

Discovery of the first NEDDylation inhibitor, that targets the NEDD8·NAE protein–protein interaction, was acheived using the Exploring Key Orientations (EKO) approach.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Jan 01, 2021
• Source ID: 10.1039/d0sc00958j

Entities

People

• Chen-Ming Lin
• Kevin Burgess
• Maritess Arancillo
• Zhe Gao
• Zhengyang Jiang

Organizations

• Cancer Prevention and Research Institute of Texas
• National Institutes of Health
• National Science Foundation
• Robert A. Welch Foundation
• Texas A&M University
• United States Department of Defense