19F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes
Abstract
This study demonstrates the screening of a collection of twelve 19F-tagged metal-binding pharmacophores (MBPs) against the Zn(ii)-dependent metalloenzyme human carbonic anhydrase II (hCAII) by 19F NMR.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2021
- Source ID
- 10.1039/d1cc01231b
Entities
People
- Alysia J. Kohlbrand
- Hyeonglim Seo
- Kathleen E Prosser
- Mark Kalaj
- Seth M Cohen
Organizations
- Achievement Rewards for College Scientists Foundation
- National Institute of Allergy and Infectious Diseases
- Natural Sciences and Engineering Research Council
- United States Army
- University of California
- Yusuf Hamied Department of Chemistry