Enzyme aggregation and fragmentation induced by catalysis relevant species

Abstract

Alkaline phosphatase, hexokinase, and glucose oxidase either aggregate or fragment after addition of species directly related to their catalysis. This shows that specific multimeric structures of native enzymes may not be retained during catalysis.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 01, 2021
Source ID
10.1039/d1cp02966e

Entities

People

  • Ashlesha Bhide
  • Ayusman Sen
  • James Adair
  • Joshua Kauffman
  • Kayla Gentile
  • Subhabrata Maiti
  • Subhadip Ghosh
  • Tae-hee Lee

Organizations

  • Air Force Office of Scientific Research
  • Pennsylvania State University

Tags

Readers

  • Molecular and Cellular Biochemistry