Squalamine and trodusquemine: two natural products for neurodegenerative diseases, from physical chemistry to the clinic
Abstract
The natural products squalamine and trodusquemine are promising potential therapeutics against Alzheimer's, Parkinson's, and other neurodegenerative diseases for their ability to modulate protein aggregation processes and target protein misfolded oligomers that are toxic to neurons.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1039/d1np00042j
Entities
People
- Denise Barbut
- Fabrizio Chiti
- Michael Zasloff
- Michele Vendruscolo
- Ryan Limbocker
- Silvia Errico
- Tuomas Knowles
Organizations
- Defense Threat Reduction Agency
- Frances and Augustus Newman Foundation
- Georgetown University
- United States Army Research Laboratory
- University of Cambridge
- University of Florence
- Yusuf Hamied Department of Chemistry