Homogeneous antibody–angiopep 2 conjugates for effective brain targeting
Abstract
Homogeneous conjugation of angiopep-2 to a monoclonal antibody improves binding affinity for brain microvascular endothelial cells and accumulation into brain tissues and tumors across the BBB.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1039/d1ra08131d
Entities
People
- Aiko Yamaguchi
- Chisato M Yamazaki
- Kyoji Tsuchikama
- Ningyan Zhang
- Wei Xiong
- Yasuaki Anami
- Zhiqiang An
Organizations
- Cancer Prevention and Research Institute of Texas
- Japan Society for the Promotion of Science
- National Institute of General Medical Sciences
- Robert A. Welch Foundation
- United States Department of Defense
- University of Texas at Austin