Adapting decarbonylation chemistry for the development of prodrugs capable of in vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules
Abstract
1,2-Dicarbonyl compounds with FDA-approved sweeteners as leaving groups deliver CO for protection against acute kidney injury in mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2021
- Source ID
- 10.1039/d1sc02711e
Entities
People
- Alyssa Cachuela
- Anna Menshikh
- Binghe Wang
- Chalet Tan
- David Gallo
- Haichun Yang
- Ladie Kimberly De La Cruz
- Leo E Otterbein
- Mark De Caestecker
- Maya Brewer
- Minjia Wang
- Siming Wang
- Wen Lu
- Xiaoxiao Yang
- Xingyue Ji
Organizations
- Beth Israel Deaconess Medical Center
- Department of Surgery
- Georgia Research Alliance
- Georgia State University
- Harvard Medical School
- National Institutes of Health
- United States Army
- United States Department of Defense
- University of Mississippi
- Vanderbilt University
- Yusuf Hamied Department of Chemistry