Discovery of phosphotyrosine-binding oligopeptides with supramolecular target selectivity
Abstract
Phage-display screening on self-assembled tyrosine-phosphate ligands enables the identification of oligopeptides selective to dynamic supramolecular targets, with the lead peptide showing a preferred hairpin-like conformation and catalytic activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1039/d1sc04420f
Entities
People
- Ana Sofia Pina
- Arménio J Moura Barbosa
- Beatriz De P. Mariz
- Bruno Miguel Morais Faustino
- Cecília Roque
- Charalampos G Pappas
- Daniela Kalafatovic
- Henrique F Carvalho
- Inês P. Moreira
- Isabel Maria Ferreira
- Krystyna L. Duncan
- Leonor Morgado
- Rein V Ulijn
- Sara Carvalho
- Tong Wang
- Vishal Narang
Organizations
- Air Force Office of Scientific Research
- CUNY Graduate School and University Center
- City University of New York
- Fundação para a Ciência e Tecnologia
- Hunter College
- NOVA University Lisbon
- Royal Society of Chemistry
- University of Strathclyde