An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold

Abstract

An unusual N-capping asparagine-lysine-proline (5NKP7) motif yields a coil/N-cap/α-helix multifunctional scaffold in a computer-made peptide selective for anionic surfaces and with anticancer, antibacterial, antibiofilm, anti-infective (in vivo), and immunomodulatory potential.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 01, 2022
Source ID
10.1039/d1sc06998e

Entities

People

  • Cesar de la Fuente-Nunez
  • Danieli F. Buccini
  • David Craik
  • Elizabete S. Cândido
  • Karen G N Oshiro
  • Lai Yue Chan
  • Marcelo D. T. Torres
  • Marlon Henrique Cardoso
  • Nuno C. Santos
  • Octávio Luiz Franco
  • Samilla B Rezende
  • Sónia Gonçalves
  • Timothy K. Lu
  • Ítala C Silva

Organizations

  • Australian Research Council
  • Coordenação de Aperfeicoamento de Pessoal de Nível Superior
  • Defense Threat Reduction Agency
  • Foundation for Research Support of the Federal District
  • Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
  • National Council for Scientific and Technological Development
  • National Institute of General Medical Sciences
  • Universidade Católica de Brasília
  • Universidade Federal de Mato Grosso do Sul
  • University of Brasília
  • University of Lisbon
  • University of Pennsylvania
  • University of Queensland

Tags

Fields of Study

  • Chemistry

Readers

  • Library and Information Science/ Studies, Southeast Asia Studies, Bibliography of Vietnam and Lao Studies.
  • Nanocomposite Materials Science
  • Oncology (Cancer Research).