Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models
Abstract
Increased microenvironmental stiffness and alveolar epithelial cells were both required to drive fibroblast activation in biomaterial-based 3D models of pulmonary fibrosis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1039/d2bm00827k
Entities
People
- Chelsea M. Magin
- David W. H. Riches
- Rachel Blomberg
- Rukshika S. Hewawasam
- Thomas Caracena
- Zoe E. Fry
Organizations
- American Thoracic Society
- Division of Materials Research
- National Cancer Institute
- National Heart, Lung, and Blood Institute
- National Jewish Health
- United States Department of Defense
- United States Department of Veterans Affairs
- University of Colorado