Increased block copolymer length improves intracellular availability of protein cargo
Abstract
Amphiphilic protein transduction domain mimics (PTDMs) of various lengths were used for protein delivery in Jurkat T cells. Although longer PTDMs facilitated greater cargo internalization, shorter PTDMs yielded greater cargo activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1039/d2py00017b
Entities
People
- Christopher R. Hango
- Esha A. Uddin
- Gregory N Tew
- Hazel C. Davis
- Lisa M Minter
Organizations
- National Science Foundation
- United States Department of Defense
- University of Massachusetts
- University of Massachusetts Amherst