Xanthone-based solvatochromic fluorophores for quantifying micropolarity of protein aggregates
Abstract
Using a single atom substitution approach, we have developed a series of solvatochromic fluorophores that respond solely to polarity. The utility of these fluorophores is demonstrated by quantifying the polarity of misfolded and aggregated proteins.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2022
- Source ID
- 10.1039/d2sc05004h
Entities
People
- Axel Loredo
- Chia-heng Hsiung
- Han Xiao
- Lushun Wang
- Shichao Wang
- Xiaojing Liu
- Xin Zhang
Organizations
- Burroughs Wellcome Fund
- Cancer Prevention and Research Institute of Texas
- John S. Dunn Foundation
- National Institutes of Health
- Pennsylvania State University
- Rice University
- Robert A. Welch Foundation
- The Pew Charitable Trusts
- United States Department of Defense