Chronic Traumatic Encephalopathy and Neuropathological Comorbidities
Abstract
With age, the presence of multiple neuropathologies in a single individual becomes increasingly common. Given that traumatic brain injury and the repetitive head impacts (RHIs) that occur in contact sports have been associated with the development of many neurodegenerative diseases, including chronic traumatic encephalopathy (CTE), Alzheimer's disease, Lewy body disease, and amyotrophic lateral sclerosis, it is becoming critical to understand the relationship and interactions between these pathologies. In fact, comorbid pathology is common in CTE and likely influenced by both age and the severity and type of exposure to RHI as well as underlying genetic predisposition. Here, we review the major comorbid pathologies seen with CTE and in former contact sports athletes and discuss what is known about the associations between RHI, age, and the development of neuropathologies. In addition, we examine the distinction between CTE and age-related pathology including primary age-related tauopathy and age-related tau astrogliopathy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 30, 2020
- Source ID
- 10.1055/s-0040-1713628
Entities
People
- John F. Crary
- Thor D Stein
Organizations
- Alzheimer's Association
- Boston University
- Icahn School of Medicine at Mount Sinai
- National Institute of Neurological Disorders and Stroke
- United States Department of Defense
- United States Department of Veterans Affairs
- VA Boston Healthcare System