Atmospheric pressure cold plasma as an antifungal therapy
Abstract
A microhollow cathode based, direct-current, atmospheric pressure, He/O2 (2%) cold plasma microjet was used to inactive antifungal resistants Candida albicans, Candida krusei, and Candida glabrata in air and in water. Effective inactivation (>90%) was achieved in 10 min in air and 1 min in water. Antifungal susceptibility tests showed drastic reduction of the minimum inhibitory concentration after plasma treatment. The inactivation was attributed to the reactive oxygen species generated in plasma or in water. Hydroxyl and singlet molecular oxygen radicals were detected in plasma-water system by electron spin resonance spectroscopy. This approach proposed a promising clinical dermatology therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 10, 2011
- Source ID
- 10.1063/1.3530434
Entities
People
- Haiyan Wu
- Jing Fang
- Jose L. Lopez
- Jue Zhang
- Peng Sun
- Ruoyu Li
- Wei Liu
- Weidong Zhu
- Yi Sun
Organizations
- Air Force Office of Scientific Research
- Peking University
- Saint Peter's University