Shock wave interaction with a phospholipid membrane: Coarse-grained computer simulations
Abstract
We used MARTINI coarse-grained force field to study poration of a lipid bilayer by a shock wave induced nanobubble collapse. Different systems containing different sized nanobubbles that were exposed to shock waves propagating with different velocities were simulated. We observed creation of pores and damage to bilayers and also subsequent pore closing and the bilayer recovery after shock wave passed the bilayer. In all our systems where bilayers were damaged, they recovered; nevertheless we observed that a large amount of water crossed the pore that was temporarily created. We also observed that not every lipid molecule remained in the bilayer after recovery, some lipids moved out into water and created micelles.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 05, 2014
- Source ID
- 10.1063/1.4862987
Entities
People
- Kolattukudy P. Santo
- Max L. Berkowitz
Organizations
- Office of Naval Research
- University of North Carolina at Chapel Hill