Limit of detection of field effect transistor biosensors: Effects of surface modification and size dependence
Abstract
Field-effect transistor biosensors have shown great promise in the detection of biomolecules. However, a quantitative understanding of what limits the smallest measurable concentration of analyte (limit of detection or LOD) is still missing. By considering the signal-to-noise ratio (SNR), extracted from a combination of noise and I-V characterization, we are able to accurately predict and experimentally confirm a LOD of 0.01 pH. Our results also show that devices with larger area and with amine functionalized surfaces have larger SNR. We are able to extract the associated oxide trap densities and, thus, quantify the improvements in LOD.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 24, 2014
- Source ID
- 10.1063/1.4867025
Entities
People
- Kara Brower
- Mark A. Reed
- Nitin K. Rajan
- Xuexin Duan
Organizations
- Army Research Office
- Yale University