Magneto-reactance based detection of MnO nanoparticle-embedded Lewis lung carcinoma cells
Abstract
We demonstrate the capacity of detecting magnetically weak manganese oxide (MnO) nanoparticles and the Lewis lung carcinoma (LLC) cancer cells that have taken up these nanoparticles using a novel biosensor based on the magneto-reactance (MX) effect of a soft ferromagnetic amorphous ribbon with a microhole-patterned surface. While the magnetic moment of the MnO nanoparticles is relatively small, and a magneto-impedance based sensor fails to detect them in solution (0.05 mg/ml manganese oxide lipid micellar nanoparticles) and inside cells at low concentrations (8.25 × 104 cells/ml), the detection of these nanoparticles and the LLC cells containing them is achieved with the MX-based sensor, which, respectively, reaches the detection sensitivity of ∼3.6% and 2.8% as compared to the blank cells. Since the MnO nanoparticles are a promising contrast agent for magnetic resonance imaging (MRI) of lung cells, the MX-based biosensing technique can be developed as a pre-detection method for MRI of lung cancer cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 17, 2015
- Source ID
- 10.1063/1.4914950
Entities
People
- H. Srikanth
- Jagannath Devkota
- M. H. Phan
- M. Howell
- Parijat Mukherjee
- Somesh Mohapatra
Organizations
- United States Army
- University of South Florida