High speed intravascular photoacoustic imaging with fast optical parametric oscillator laser at 1.7 μm
Abstract
Intravascular photoacoustic imaging at 1.7 μm spectral band has shown promising capabilities for lipid-rich vulnerable atherosclerotic plaque detection. In this work, we report a high speed catheter-based integrated intravascular photoacoustic/intravascular ultrasound (IVPA/IVUS) imaging system with a 500 Hz optical parametric oscillator laser at 1725 nm. A lipid-mimicking phantom and atherosclerotic rabbit abdominal aorta were imaged at 1 frame per second, which is two orders of magnitude faster than previously reported in IVPA imaging with the same wavelength. Clear photoacoustic signals by the absorption of lipid rich deposition demonstrated the ability of the system for high speed vulnerable atherosclerotic plaques detection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 24, 2015
- Source ID
- 10.1063/1.4929584
Entities
People
- Chang-seok Kim
- Jiawen Li
- K. Kirk Shung
- Maximilian T. Wiedmann
- Mingyue Yu
- Qifa Zhou
- Shenghai Huang
- Teng Ma
- Zhonglie Piao
- Zhongping Chen
Organizations
- Air Force Office of Scientific Research
- Foundation for the National Institutes of Health
- National Institutes of Health
- National Research Foundation of Korea
- Pusan National University
- University of California
- University of Southern California