Enhancing sensitivity of lateral flow assay with application to SARS-CoV-2
Abstract
Lateral flow assay (LFA) has long been used as a biomarker detection technique. It has advantages such as low cost, rapid readout, portability, and ease of use. However, its qualitative readout process and lack of sensitivity are limiting factors. We report a photon-counting approach to accurately quantify LFAs while enhancing sensitivity. In particular, we demonstrate that the density of SARS-CoV-2 antibodies can be quantified and measured with an enhanced sensitivity using this simple laser optical analysis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 21, 2020
- Source ID
- 10.1063/5.0021842
Entities
People
- Aleksei Zheltikov
- Alexei Sokolov
- Anatoly A. Svidzinsky
- Benjamin W. Neuman
- Bruce Akey
- Chao-Yang Lu
- Da-Wei Wang
- Edward Fry
- G. S. Agarwal
- George Kattawar
- Jane Pryor
- Jeffrey Cirillo
- Jianwei Pan
- Jon Mogford
- L. Garry Adams
- Marlan Scully
- Ming-che Lee
- Moochan Kim
- Navid Rajil
- Philip Hemmer
- Reed Nessler
- Sahar Delfan
- Tao Peng
- Volker Deckert
- Xiangpei Liu
- Xiaoyu Nie
- Yanhua Shih
- Zehua Han
- Zhenhuan Yi
Organizations
- Air Force Office of Scientific Research
- Baylor University
- Friedrich Schiller University Jena
- German Research Foundation
- King Abdulaziz City for Science and Technology
- Leibniz Institute of Photonic Technology
- Moscow State University
- National Science Foundation
- Office of Naval Research
- Princeton University
- Robert A. Welch Foundation
- Texas A&M University
- University of Maryland, Baltimore County
- University of Science and Technology of China
- Xi'an Jiaotong University
- Zhejiang University