Toward improved models of human cancer
Abstract
Human cancer is a complex and heterogeneous collection of diseases that kills more than 18 million people every year worldwide. Despite advances in detection, diagnosis, and treatments for cancers, new strategies are needed to combat deadly cancers. Models of human cancer continue to evolve for preclinical research and have culminated in patient-derived systems that better represent the diversity and complexity of cancer. Still, no model is perfect. This Perspective attempts to address ways that we can improve the clinical translatability of models used for cancer research, from the point of view of researchers who mainly conduct cancer studies in vivo.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 04, 2021
- Source ID
- 10.1063/5.0030534
Entities
People
- Alana L Welm
- Bryan E. Welm
- Christos Vaklavas
Organizations
- National Cancer Institute
- United States Department of Defense
- University of Utah