Graphene nanostructures for input–output bioelectronics
Abstract
The ability to manipulate the electrophysiology of electrically active cells and tissues has enabled a deeper understanding of healthy and diseased tissue states. This has primarily been achieved via input/output (I/O) bioelectronics that interface engineered materials with biological entities. Stable long-term application of conventional I/O bioelectronics advances as materials and processing techniques develop. Recent advancements have facilitated the development of graphene-based I/O bioelectronics with a wide variety of functional characteristics. Engineering the structural, physical, and chemical properties of graphene nanostructures and integration with modern microelectronics have enabled breakthrough high-density electrophysiological investigations. Here, we review recent advancements in 2D and 3D graphene-based I/O bioelectronics and highlight electrophysiological studies facilitated by these emerging platforms. Challenges and present potential breakthroughs that can be addressed via graphene bioelectronics are discussed. We emphasize the need for a multidisciplinary approach across materials science, micro-fabrication, and bioengineering to develop the next generation of I/O bioelectronics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 01, 2021
- Source ID
- 10.1063/5.0073870
Entities
People
- Daniel San Roman
- Devora Cohen-Karni
- Itzhaq Cohen-Karni
- Raghav Garg
- Yingqiao Wang
Organizations
- Carnegie Mellon University
- Defense Advanced Research Projects Agency
- Lake Erie College of Osteopathic Medicine
- National Institute of Biomedical Imaging and Bioengineering
- National Science Foundation