Mechanisms of NDV-3 vaccine efficacy in MRSA skin versus invasive infection
Abstract
Staphylococcus aureus is an opportunistic pathogen of the normal human flora. It is among the most frequent causes of cutaneous abscesses, leading to life-threatening invasive infection. Incomplete understanding of host defenses against S. aureus skin or invasive infection has hindered development of effective vaccines to address these issues. NDV-3 is a unique cross-kingdom vaccine targeting S. aureus and Candida albicans . The present studies offer important new evidence: ( i ) NDV-3 protects against methicillin-resistant S. aureus skin and skin structure infection largely through IL-22– and IL-17A–mediated host defense peptide and neutrophil induction, ( ii ) vaccine-mediated IL-22 and IL-17A play distinct roles in protection against cutaneous versus invasive infection, and ( iii ) NDV-3 vaccine efficacy in this model involves a coordinated induction of innate and adaptive immunity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 08, 2014
- Source ID
- 10.1073/pnas.1415610111
Entities
People
- Ashraf S. Ibrahim
- Clint S. Schmidt
- Deborah Kupferwasser
- Huiyuan Wang
- John E. Edwards Jr.
- John P. Hennessey Jr.
- Kevin Barr
- Michael R. Yeaman
- Scott G. Filler
- Siyang Chaili
- Yan Q. Xiong
- Yue Fu
Organizations
- United States Department of Defense
- University of California, Los Angeles