STEP 61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson’s disease
Abstract
In neurons, STEP 61 (striatal-enriched protein tyrosine phosphatase) protein levels are tightly regulated, and the protein’s up-regulation is implicated in several neuropsychiatric disorders. Here, we demonstrate that parkin is a major E3 ligase regulating STEP 61 levels through the ubiquitin proteasome system. In Parkinson’s disease, in which parkin function is compromised, STEP 61 levels increase, which is associated with down-regulation of synaptic proteins required for neuronal plasticity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 12, 2015
- Source ID
- 10.1073/pnas.1417423112
Entities
People
- Angus C. Nairn
- Chimezie Ononenyi
- Graça Baltazar
- Jian Xu
- Paul J. Lombroso
- Pradeep K. Kurup
- Rita Alexandra Videira
Organizations
- National Institute of Mental Health
- The Michael J. Fox Foundation
- United States Department of Defense
- University of Beira Interior
- Yale Child Study Center
- Yale University