Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt
Abstract
Reduced sleep duration is a hallmark of modern-day society and is increasingly associated with medical conditions, such as diabetes, obesity, metabolic syndrome, and cardiovascular disease. Here we present data from a rat model and human clinical study of chronic sleep restriction, both revealing that two metabolites in blood, oxalic acid and diacylglycerol 36:3, are quantitatively depleted under sleep-restricted conditions and restored after recovery sleep. Our findings also reveal a significant overall shift in lipid metabolism, with higher levels of phospholipids in both species and evidence of a systemic oxidative environment. This work provides a potential link between the known pathologies of reduced sleep duration and metabolic dysfunction.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 09, 2015
- Source ID
- 10.1073/pnas.1417432112
Entities
People
- Aalim M. Weljie
- Amita Sehgal
- Arjun Sengupta
- David F. Dinges
- Matthew S Kayser
- Morris J. Birnbaum
- Namni Goel
- Peter Meerlo
- Ted Abel
Organizations
- Howard Hughes Medical Institute
- National Aeronautics and Space Administration
- National Institute of Nursing Research
- University of Groningen
- University of Pennsylvania