Nitric oxide regulates synaptic transmission between spiny projection neurons
Abstract
The function of the basal ganglia relies on striatal spiny projecting neurons (SPNs). Axon collaterals of these GABAergic neurons form connections with other SPNs as a means of a feedback inhibition circuit. The mechanisms that regulate neurotransmission at these local synapses remain poorly understood. In this paper, neurotransmission at SPN collaterals is found to be regulated by the gaseous neurotransmitter nitric oxide, which activates a signal-transduction cascade that transcriptionally regulates vesicular GABA transporter specifically at axon collaterals. These findings illustrate a previously unidentified role for nitric oxide in striatal learning and action selection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 20, 2014
- Source ID
- 10.1073/pnas.1420162111
Entities
People
- Dalton J. Surmeier
- Jayms D. Peterson
- Mariangela Scarduzio
- Michael G. Kaplitt
- Myriam Heiman
- Nathaniel Heintz
- Paul Greengard
- Sergei Musatov
- Stephen M. Logan
- Yotam Sagi
Organizations
- Cornell University
- Fisher Center for Alzheimer's Research Foundation
- Laboratory of Molecular Biology
- Northwestern University
- Telemedicine and Advanced Technology Research Center
- The Rockefeller University
- United States Army Medical Research and Development Command