Differential regulation of the Hippo pathway by adherens junctions and apical–basal cell polarity modules
Abstract
The control of organ growth involves cell–cell communication that is mediated by signal transduction pathways. The Hippo signaling pathway has emerged as an essential regulator of organ size in Drosophila and mammals, and defects in Hippo signaling drive cancer progression. An important unresolved question in the growth control field is, How is the Hippo pathway regulated? Recent reports show that adherens junctions and cell polarity complexes regulate the Hippo pathway, but controversy exists about the mechanisms involved. Here we report that in Drosophila and in mammalian cells, adherens junctions and basolateral polarity complexes regulate the Hippo pathway independently of each other. These results thus deepen our knowledge of this important growth control and tumor suppressor pathway.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 26, 2015
- Source ID
- 10.1073/pnas.1420850112
Entities
People
- Andrew B Gladden
- Chih-chao Yang
- Chunyao Tao
- Fisun Hamaratoglu
- Georg Halder
- Hillary K. Graves
- Ivan M. Moya
Organizations
- Katholieke Universiteit Leuven
- United States Department of Defense
- University of Lausanne
- University of Texas at Austin