Tunable control of antibody immobilization using electric field
Abstract
We introduce a novel method for controlling orientation of proteins during immobilization on solid-state surfaces using electric fields. Atomic force microscopy measurements and fluorescence-based readout are used to confirm this phenomenon. This method of immobilization has broad implications for improvement in performance of both affinity-based protein assays and probe-free detection assays.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 03, 2015
- Source ID
- 10.1073/pnas.1424592112
Entities
People
- Chaitanya Gupta
- Mehdi Javanmard
- Roger T. Howe
- Ronald W. Davis
- Sam Emaminejad
- Shuai Chang
Organizations
- National Human Genome Research Institute
- Rutgers University
- Stanford University