PDGFB-based stem cell gene therapy increases bone strength in the mouse
Abstract
Osteoporosis is a morbid disease afflicting millions of people worldwide. To unlock the unique regenerative powers of the skeleton that have not yet been exploited, we used stem cell gene therapy to dramatically increase bone formation at sites where bone is lost during osteoporosis. Our therapy tremendously increased de novo trabecular bone formation and trabecular connections, resulting in a large increase in bone strength. Our therapy has clinical potential, may serve as a prototype for future skeletal stem cell gene therapies, and is a model for mechanistic studies of de novo trabecular bone formation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 06, 2015
- Source ID
- 10.1073/pnas.1501759112
Entities
People
- Amanda Neises
- Charles H Rundle
- David J. Baylink
- Jason B. Kiroyan
- Justin Brier-jones
- Kin-Hing Lau
- Wanqiu Chen
- Xiao-bing Zhang
Organizations
- Loma Linda University
- Telemedicine and Advanced Technology Research Center