Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone
Abstract
Smartphones and wearable electronics have advanced tremendously over the last several years but fall short of allowing their use for molecular diagnostics. We herein report a generic approach to enable molecular diagnostics on smartphones. The method utilizes molecular-specific microbeads to generate unique diffraction patterns of “blurry beads” which can be recorded and deconvoluted by digital processing. We applied the system to resolve individual precancerous and cancerous cells as well as to detect cancer-associated DNA targets. Because the system is compact, easy to operate, and readily integrated with the standard, portable smartphone, this approach could enable medical diagnostics in geographically and/or socioeconomically limited settings with pathology bottlenecks.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 13, 2015
- Source ID
- 10.1073/pnas.1501815112
Entities
People
- Brady Magaoay
- Cesar M Castro
- Changwook Min
- Divya Pathania
- Hakho Lee
- Huilin Shao
- Hyungsoon Im
- Jun Song
- Junsung Rho
- Lioubov Fexon
- Maria Avila-wallace
- Misha Pivovarov
- Monty Liong
- Omar Zurkiya
- Ralph Weissleder
- Rosemary H. Tambouret
Organizations
- Harvard Medical School
- Harvard University
- Massachusetts General Hospital
- National Cancer Institute
- National Institutes of Health
- United States Department of Defense