Immunomodulatory spherical nucleic acids
Abstract
We show that by organizing immunomodulatory nucleic acids into spherical nucleic acid (SNA) form, significant increases in activity are observed. Treatment of mice with cancer using immunostimulatory SNAs and nonalcoholic steatohepatitis (NASH) using immunoregulatory SNAs leads to improved disease outcomes vs. their unstructured counterparts. These improvements derive from several key SNA properties, including rapid cellular uptake, endosomal delivery, and multivalent binding. Overall, this work underscores the importance of the spatial orientation and presentation of oligonucleotides in the design of novel immunomodulators.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 16, 2015
- Source ID
- 10.1073/pnas.1502850112
Entities
People
- Aleksandar F. Radovic-moreno
- Chad Mirkin
- Christopher C. Mader
- Clayton H Rische
- David A. Walker
- Liangliang Hao
- Merideth Burkhart
- Natalia Chernyak
- Richard S. Kang
- Sagar Anantatmula
- Sergei M. Gryaznov
- Subbarao Nallagatla
- Tiffany L. Halo
- Timothy J. Merkel
Organizations
- National Cancer Institute
- Northwestern University