Microdroplet fusion mass spectrometry for fast reaction kinetics
Abstract
Time-resolved mass spectrometry is a powerful approach for identifying reaction intermediates and measuring reaction kinetics, yet one critical limitation is temporal resolution. Here, we describe microdroplet fusion mass spectrometry on timescales as short as microseconds. In our approach, two high-speed streams of liquid microdroplets collide to make fused droplets of 13 ± 6 μm in diameter, where the reactants are mixed in a negligible time. After a short flying time of 50 μs or less during which the reaction proceeds, the fused droplets enter a mass spectrometer for chemical analysis of intermediates and reaction products. This enables observation of early events of various fast chemical reactions in the liquid phase.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 16, 2015
- Source ID
- 10.1073/pnas.1503689112
Entities
People
- Hong Gil Nam
- Jae Kyoo Lee
- Richard Zare
- Samuel Kim
Organizations
- Air Force Office of Scientific Research
- Daegu Gyeongbuk Institute of Science and Technology
- Institute for Basic Science
- Stanford University