Regional specialization within the human striatum for diverse psychological functions
Abstract
The subcortical striatum is critical for the planning and execution of motor behavior, and its dysfunction is associated with disorders such as Parkinson’s disease. More recently, the human striatum has also been reported to be involved in heterogeneous nonmotor psychological functions. However, detailed functional mappings of human psychological processes to striatal regions have been bound by theoretical and methodological limitations, including a strong focus on experimental paradigms derived from animal research, and the tendency to infer function from anatomical connectivity, rather than task-related activation. To overcome these limitations, we used a large-scale, unbiased, data-driven approach, and generated a precise, comprehensive functional map, directly associating striatal zones with the broadest range of psychological processes to date.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 01, 2016
- Source ID
- 10.1073/pnas.1507610113
Entities
People
- Randall C. O'Reilly
- Tal Yarkoni
- Tor D. Wager
- Wolfgang M. Pauli
Organizations
- California Institute of Technology
- National Institute of Mental Health
- National Institutes of Health
- Office of Naval Research Global
- University of Colorado Boulder
- University of Texas at Austin