Functional and topological diversity of LOV domain photoreceptors
Abstract
Photoreceptor proteins dynamically control many critical physiological processes in response to light across the whole phylogenetic order, including the regulation of circadian rhythms and photosynthesis. We created a comprehensive catalog of the protein architectures and biochemical functions of a ubiquitous class of natural photoreceptors, the light–oxygen–voltage sensitive (LOV) class of flavoproteins, including >4,000 new candidate LOVs, which nearly triples the sequence diversity known to date. Establishing the functional and structural diversity of LOVs will (i) shed light on how organisms adapt to environmental changes, (ii) elucidate the structure–function principles by which common photosensory inputs are transmitted into a multitude of cell signaling events, and (iii) beget novel “optogenetic” tools for light-driven physiological perturbation of cells expressing natural or engineered photoreceptors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 29, 2016
- Source ID
- 10.1073/pnas.1509428113
Entities
People
- Brian Y. Chow
- Edward Boyden
- Eric J. Carpenter
- Gane Ka-shu Wong
- Kevin H. Gardner
- Michael Melkonian
- Spencer T. Glantz
Organizations
- Alberta Innovates
- Alfred P. Sloan Foundation
- BGI Genomics
- Brain Research Foundation
- Cancer Prevention and Research Institute of Texas
- City College of New York
- City University of New York
- Division of Chemical, Bioengineering, Environmental, and Transport Systems
- Human Frontier Science Program
- Institution of Engineering and Technology
- Massachusetts Institute of Technology
- National Institute of General Medical Sciences
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- National Institute on Drug Abuse
- New York Stem Cell Foundation
- Office of Emerging Frontiers and Multidisciplinary Activities
- Office of the Director
- Office of the Secretary of Defense
- University of Alberta
- University of Cologne
- University of Pennsylvania
- W. W. Smith Charitable Trust
- Wallace H. Coulter Foundation