Micromechanics of cellularized biopolymer networks
Abstract
Mechanical interactions between cells, mediated by the elastic response of the extracellular matrix to active applied forces, play a critical role in developmental biology, wound healing, and cancer progression. This work applies sophisticated technical means, both in experiment and computational modeling, to investigate the micron-scale mechanics of a popular model of this medium, a collagen gel. The results obtained show clearly that on the cellular scale, there are significant spatial variations in the micromechanics due to network heterogeneities.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 31, 2015
- Source ID
- 10.1073/pnas.1509663112
Entities
People
- Bo Sun
- Christopher A. R. Jones
- David H. Mcintyre
- Emma A. Krnacik
- Herbert Levine
- Jingchen Feng
- Matthew Cibula
Organizations
- National Science Foundation
- Office of Naval Research
- Oregon State University
- Rice University