Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice
Abstract
G protein-coupled receptors constitute an important class of receptors and represent a family of choice for therapeutic interventions for multiple diseases and disorders. One of these metabotropic glutamate receptors, mGluR5, is highly relevant because of its biological importance for various medical conditions, including major depressive disorder (MDD). In a search of mGluR5 modulators we identified Norbin as a key regulator. Here we demonstrate in vivo that Norbin significantly influences hippocampal neurogenesis and that both the proliferation and survival of newborn neurons are impaired in the absence of Norbin. Furthermore, the use of three well-established behavioral paradigms indicated that Norbin-KO mice display depressive-like characteristics. Thus interventions that could boost Norbin function might be beneficial to treat MDD symptoms.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 20, 2015
- Source ID
- 10.1073/pnas.1510291112
Entities
People
- Grigori Enikolopov
- Hong Wang
- Jennifer Warner-schmidt
- Marc Flajolet
- Paul Greengard
- Santiago Varela
Organizations
- Cold Spring Harbor Laboratory
- National Institute of Mental Health
- National Institute on Drug Abuse
- Telemedicine and Advanced Technology Research Center
- The Rockefeller University