Zwitterionic gel encapsulation promotes protein stability, enhances pharmacokinetics, and reduces immunogenicity
Abstract
A protein modification technology has been developed in this study to overcome current problems faced by protein therapy. After being individually encapsulated in a super-hydrophilic zwitterionic gel, a therapeutic protein showed exceptional stability and long in vivo circulation half-life. More importantly, no immune response against either the protein or the polymer was observed following repeated injections. This technology will benefit patients by reducing administration frequency and mitigating adverse reactions and could allow more immunogenic proteins to enter into human therapeutic or protective applications.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 14, 2015
- Source ID
- 10.1073/pnas.1512465112
Entities
People
- Andrew Sinclair
- Caroline Tsao
- Fang Sun
- Hsiang-Chieh Hung
- Kan Wu
- Peng Zhang
- Priyesh Jain
- Shaoyi Jiang
- Sijun Liu
- Tao Bai
Organizations
- Defense Threat Reduction Agency
- National Institute of Biomedical Imaging and Bioengineering
- University of Washington