SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis
Abstract
Discovery of novel metastasis suppressor genes in breast cancer using genomic efforts has been limited, potentially due to overlooking their regulation by epigenetic mechanisms. We report the discovery of SDPR as a novel metastasis suppressor gene localized to 2q32-33, a region associated with significant loss of heterozygosity in breast cancer, using comparative gene expression analysis of a breast cancer progression model system in conjunction with in silico metaanalysis of publicly available datasets. SDPR is silenced epigenetically by promoter DNA methylation and its loss of expression correlates with significantly reduced distant-metastasis–free and relapse-free survival of breast cancer patients. Overexpression of SDPR reduces cell migration and intravasation/extravasation potential, favors cell death, and suppresses experimental lung metastasis of breast cancer cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 06, 2016
- Source ID
- 10.1073/pnas.1514663113
Entities
People
- Arthur W. Lambert
- Arunthathi Thiagalingam
- Chen Khuan Wong
- Hamid M. Abdolmaleky
- Herbert T. Cohen
- Panagiotis Papageorgis
- Sait Ozturk
- Sam Thiagalingam
Organizations
- Boston University
- National Institutes of Health
- Research Promotion Foundation
- Susan G. Komen for the Cure
- United States Department of Defense