Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels
Abstract
The secretion of aqueous humor from the ciliary body is regulated by osmotic gradients, yet the mechanism through which these cells sense these gradients is still under debate. We have identified the calcium-permeable transient receptor potential vanilloid isoform 4 (TRPV4) ion channel as critical for translating hypotonic stimuli into intracellular signals and linked the activation of this channel to a known proinflammatory lipid signaling pathway. The channel was confined to nonpigmented cells that secrete aqueous fluid and regulate intraocular pressure. Thus, activation of TRPV4 may contribute to vision through metabolic support of anterior eye tissues and regulation of osmotic and tensile homeostasis within the eye.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 22, 2016
- Source ID
- 10.1073/pnas.1515895113
Entities
People
- Amber M. Frye
- Andrew O. Jo
- Bruce A. Berkowitz
- David Križaj
- Monika Lakk
- Oleg Yarishkin
- Robin Roberts
- Sarah N. Redmon
- Tam T. T. Phuong
Organizations
- National Eye Institute
- Telemedicine and Advanced Technology Research Center
- University of Utah
- Wayne State University