Evolutionary origins of hepatitis A virus in small mammals
Abstract
The origins of human hepatitis A virus (HAV) are unknown. We conducted a targeted search for HAV-related viruses in small mammals sampled globally and discovered highly diversified viruses in bats, rodents, hedgehogs, and shrews. We demonstrate that these viruses share unique biological features with HAV, including structural, genomic, antigenic, and pathogenic properties. We found evidence of major shifts of HAV-related viruses between mammalian hosts in the past, suggesting both an origin of this viral genus in small mammals and a zoonotic origin of human HAV. Our data show that risk assessments for emerging viruses can benefit greatly from the analysis of viral infection patterns that evolved within animal reservoirs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 02, 2015
- Source ID
- 10.1073/pnas.1516992112
Entities
People
- Alexander N. Lukashev
- Alexandre Hassanin
- Alvaro Aguilar Setién
- Anatoly P. Gmyl
- Andrea Rasche
- Andreas Dotzauer
- Antje Seebens-hoyer
- Chantal B. E. M. Reusken
- Chantal G. Akoua-koffi
- Christian Drosten
- David A. Wilkinson
- Detlev H. Krüger
- Elena V. Godlevska
- Elisabeth Fichet-calvet
- Eric M. Leroy
- Florian Gloza-rausch
- Guy-crispin Gembu Tungaluna
- Hui Feng
- Jan Felix Drexler
- Jan Ter Meulen
- Jonas Schmidt-chanasit
- Judith M. A. Van Den Brand
- Julia Schneider
- Konstans Wells
- Lamine Koivogui
- Leonid Lavrenchenko
- Lonneke M. Leijten
- Maklarin B. Lakim
- Marco Tschapka
- Maria João Ramos Pereira
- Nicole Seggewiβ
- Peter Vallo
- Rainer G. Ulrich
- Ramón Seage Ameneiros
- Samuel Oppong
- Sebastian Brünink
- Sonja Matthee
- Stanley M. Lemon
- Steven M. Goodman
- Tamás Görföl
- The Hepatovirus Ecology Consortium
- Thijs Kuiken
- Tom Wegner
- Victor M. Corman
- Wolfgang Preiser
- Yaw Adu-sarkodie
Organizations
- Erasmus MC
- Friedrich Loeffler Institute
- German Research Foundation
- Moscow State University
- National Institutes of Health
- Ulm University
- University of Bonn
- University of Bremen
- University of North Carolina at Chapel Hill