HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
Abstract
Uncontrolled cell proliferation and abnormal blood vessel formation result in regions of breast cancers that are hypoxic (deprived of oxygen). Hypoxia-inducible factors (HIFs) stimulate the expression of genes that enable cancer cells to invade and metastasize, leading to patient mortality. In this paper, we report that HIFs stimulate the production of CD47, a protein on the cell surface that enables cancer cells to avoid destruction by macrophages. CD47 is also important for maintaining cancer stem cells, which are a small population of cells that are required for the formation of primary tumors and metastases. Reduction of HIF activity or CD47 levels in breast cancer cells led to increased killing by macrophages and depletion of cancer stem cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 28, 2015
- Source ID
- 10.1073/pnas.1520032112
Entities
People
- Chuanzhao Zhang
- Daniele M. Gilkes
- Debangshu Samanta
- Gregg L. Semenza
- Haiquan Lu
- Huimin Zhang
- Jianjun He
- John W. Bullen
- Lisha Xiang
Organizations
- American Cancer Society
- Johns Hopkins University
- United States Department of Defense
- Xi'an Jiaotong University