Genetic background and epigenetic modifications in the core of the nucleus accumbens predict addiction-like behavior in a rat model
Abstract
Determining the factors that render an individual more susceptible or resilient to cocaine addiction has great implications for treatment. We exploit a unique model to demonstrate that genetic differences in vulnerability to cocaine addiction exist in the rat. We examined gene expression and the epigenetic regulation of two genes—fibroblast growth factor (FGF2) and the dopamine D2 receptor (D2)—in the nucleus accumbens core. Low levels of D2 mRNA, via epigenetic modifications, may play a role in susceptibility to cocaine addiction. Specifically, binding of a repressive mark on histones (H3K9me3) at the D2 promoter is associated with the propensity to relapse. In contrast, low levels of FGF2, which persist even following prolonged self-administration, may protect individuals from cocaine addiction.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 25, 2016
- Source ID
- 10.1073/pnas.1520491113
Entities
People
- Huda Akil
- Maria Waselus
- Rebeca Kelly
- Robert C. Thompson
- Salima Sewani
- Sarah M. Clinton
- Shelly B. Flagel
- Sraboni Chaudhury
- Stanley J. Watson Jr.
Organizations
- National Institute on Drug Abuse
- Office of Naval Research
- University of Alabama at Birmingham
- University of Michigan