Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer
Abstract
Survival of cancer patients can be greatly improved by an ideal theranostic platform capable of early detection and effective treatment of tumors. Layer-by-layer (LbL) assembly is a well-established technology and matches the requirement of modularity and versatility for such a theranostic platform. Second near-infrared window (NIR-II) fluorescence imaging is a promising modality with high resolution, deep penetration, and diminished noise. This work, for the first time to our knowledge, establishes a modular and versatile LbL platform for NIR-II agents and presents a head-to-head in vivo comparison of available NIR-II probes. We successfully achieve the selective, noninvasive, and safe detection of high-grade serous ovarian tumors in an orthotopic murine model. These LbL NIR-II probes promise the development of an NIR-II based theranostic platform of disease diagnosis, progression, and treatment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 25, 2016
- Source ID
- 10.1073/pnas.1521175113
Entities
People
- Angela M. Belcher
- Geran Zhang
- Jifa Qi
- Li Gu
- Paula T. Hammond
- Santiago Correa
- Xiangnan Dang
Organizations
- Massachusetts Institute of Technology
- National Cancer Institute
- National Science Foundation
- United States Department of Defense