Functional network inference of the suprachiasmatic nucleus
Abstract
In mammals, circadian rhythms are controlled by a network of neurons in the brain. The structure of this network dictates organism-wide behavior and adaptation to the environment. We used a neurotoxin to desynchronize this circadian network and then used tools from information theory to determine which cells communicate to establish synchronization. Our results show that this functional network consists of two densely-connected cores, surrounded by sparsely connected shell regions. These findings represent the first time, to our knowledge, that this network has been examined at single cell resolution and show that the importance of these core network regions is independent of light input.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 04, 2016
- Source ID
- 10.1073/pnas.1521178113
Entities
People
- Benjamin B. Bales
- Daniel Granados-fuentes
- Erik D. Herzog
- Francis J. Doyle III
- John H. Abel
- Kirsten Meeker
- Linda Petzold
- Peter C. St. John
- Thomas J. Wang
Organizations
- Army Research Office
- Harvard University
- National Institutes of Health
- National Renewable Energy Laboratory
- University of California
- Washington University in St. Louis