Global environmental drivers of influenza
Abstract
Patterns of influenza outbreak are different in the tropics than in temperate regions. Although considerable experimental progress has been made in identifying climate-related drivers of influenza, the apparent latitudinal differences in outbreak patterns raise basic questions as to how potential environmental variables combine and act across the globe. Adopting an empirical dynamic modeling framework, we clarify that absolute humidity drives influenza outbreaks across latitudes, find that the effect of absolute humidity on influenza is U-shaped, and show that this U-shaped pattern is mediated by temperature. These findings offer a unifying synthesis that explains why experiments and analyses disagree on this relationship.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 31, 2016
- Source ID
- 10.1073/pnas.1607747113
Entities
People
- Ethan R Deyle
- George Sugihara
- M. Cyrus Maher
- Ryan D. Hernandez
- Sanjay Basu
Organizations
- Human Longevity
- National Science Foundation
- Stanford University
- United States Department of Defense
- University of California
- University of California, San Francisco