Oxygen delivery using engineered microparticles
Abstract
The clinical treatment of profound oxygen deprivation (hypoxemia) is time sensitive and requires skill and specialized equipment. When the airways or lungs become incapacitated (e.g., due to airway obstruction or lung injury), resuscitation is ineffective until oxygenation is restored. Many critically ill patients suffer organ dysfunction, cardiac arrest, or death within minutes. In this work, we describe a polymeric microparticle-based oxygen delivery technology capable of rapidly administering large volumes of oxygen gas through an intravenous line.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 17, 2016
- Source ID
- 10.1073/pnas.1608438113
Entities
People
- Alexis R. Cole
- Andrew T. Lock
- Brian D Polizzotti
- Dorothy A Perry
- John N Kheir
- Raymond P. Seekell
- Yifeng Peng
Organizations
- Boston Children's Hospital
- Harvard Medical School
- United States Department of Defense