FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1
Abstract
The findings of this study have revealed a potential molecular pathway for how fatty acid synthase (FASN) overexpression causes drug and radiation resistance and contributes to poor clinical prognosis of cancer diseases. FASN is the sole cytosolic enzyme responsible for de novo lipid synthesis, required for cancer cell survival but not for most normal nonadipose tissues. The finding that FASN regulates DNA repair by regulating specificity protein 1 and NF-κB in cancer cell responses to anticancer treatments will have a profound impact on designing future treatment strategies. It will also help establish FASN as a target for therapeutic discovery to sensitize drug and radiation resistance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 24, 2016
- Source ID
- 10.1073/pnas.1609934113
Entities
People
- Chao J Wang
- Jian-Ting Zhang
- Jing-yuan Liu
- Lincoln James Barlow
- Moises A. Serrano
- Valerie Fako
- Xi Wu
- Yue Zou
- Zizheng Dong
Organizations
- Congressionally Directed Medical Research Programs
- East Tennessee State University
- Indiana University
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis
- National Cancer Institute