Paradoxical signaling regulates structural plasticity in dendritic spines
Abstract
The basis for learning and memory formation is in tiny ( 1 − 2 μm) membranous protrusions along short branched extensions (dendrites) of nerve cells (neurons) called dendritic spines. Recently, common themes have begun to emerge in identifying the cellular basis of many conditions associated with learning and memory, mainly through the observation of dynamic changes to the dendritic spine. The ability of the dendritic spine to grow, shrink, and change shape has long been associated with synaptic plasticity, learning, and memory. We develop a mathematical model that couples the biochemical signaling machinery and the actin remodeling events to provide insight into the dynamics of the dendritic spine.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 22, 2016
- Source ID
- 10.1073/pnas.1610391113
Entities
People
- George Oster
- Michael G. Levy
- Padmini Rangamani
- Shahid Ullah Khan
Organizations
- Air Force Office of Scientific Research
- Molecular Biology Consortium
- National Institute of General Medical Sciences
- University of California, San Diego