Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
Abstract
Monitoring human organ-on-a-chip systems presents a significant challenge, where the capability of in situ continual monitoring of organ behaviors and their responses to pharmaceutical compounds over extended periods of time is critical in understanding the dynamics of drug effects and therefore accurate prediction of human organ reactions. In this work, we report a fully integrated modular physical, biochemical, and optical sensing platform, interfaced through a fluidics-routing breadboard with a multi–organ-on-a-chip system to achieve in situ, continual, and automated sensing of microenvironment biophysical and biochemical parameters. It is anticipated that our platform technology that is conveniently compatible with existing organ-on-a-chip models will potentially enhance their performance in drug screening by providing a multitude of sensing data not previously available.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 06, 2017
- Source ID
- 10.1073/pnas.1612906114
Entities
People
- Adel Pourmand
- Ahmad Manbohi
- Aleksander Skardal
- Alessandro Polini
- Ali Khademhosseini
- Amir Sanati Nezhad
- Anthony Atala
- Antonia Silvestri
- Colin E. Bishop
- Duckjin Kim
- Erica Budina
- Fabio De Ferrari
- Giovanni Calzone
- Huseyin Avci
- Jian Kang
- João Ribas
- Julio Aleman
- Mehmet Remzi Dökmeci
- Ning Hu
- Noor Shaikh
- Nupura Bhise
- Parissa Alerasool
- Reza Riahi
- Seyed Ali Mousavi Shaegh
- Solange Massa
- Su Ryon Shin
- Sukyoung Chae
- Thomas Shupe
- Tuğba Kılıç
- Weijia Zhang
- Yu Shrike Zhang
Organizations
- Defense Threat Reduction Agency
- Fudan University
- Harvard Medical School
- Harvard University
- Iranian National Institute for Oceanography and Atmospheric Science
- King Abdulaziz University
- Konkuk University
- Mashhad University of Medical Sciences
- National Institutes of Health
- Osmangazi University
- Polytechnic University of Turin
- Tabriz University of Technology
- Universidad de los Andes
- University of Calgary
- University of Coimbra
- University of Toronto
- Wake Forest Institute for Regenerative Medicine
- Zhejiang University