Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer
Abstract
A high nuclear Notch homolog 1, translocation-associated (Notch1) intracellular domain level distinguishes high-risk prostate cancer and castration-resistant prostate cancer from benign and low/intermediate-risk prostate cancer. Chronic activation of Notch1 cooperates with multiple oncogenic pathways altered in early prostate cancer, including AKT, Myc, and Ras/Raf/MAPK, to promote progression to androgen ablation-resistant prostate adenocarcinoma.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 30, 2016
- Source ID
- 10.1073/pnas.1614529113
Entities
People
- Andrew S Goldstein
- Behdokht Nowroozizadeh
- Brandon Castor
- Bryan A. Smith
- Catherine C. Going
- Claire M. Faltermeier
- Donghui Cheng
- En-Chi Hsu
- Jiaoti Huang
- John K Lee
- Justin M Drake
- Kelvin X. Zhang
- Kenneth J. Pienta
- Meghan A Rice
- Mireille Riedinger
- Owen N Witte
- Robert E. Reiter
- Sandra Y. Orellana
- Sharon J Pitteri
- Shu Lin
- Steven M. Blum
- Tanya Stoyanova
Organizations
- Brigham and Women's Hospital
- Division of Cancer Prevention, National Cancer Institute
- Duke University
- Johns Hopkins School of Medicine
- National Cancer Institute
- Prostate Cancer Foundation
- Rutgers University–New Brunswick
- Stanford University
- United States Department of Defense
- University of California
- University of California, Los Angeles