Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood
Abstract
Multiple sclerosis (MS) is classified as an autoimmune disease of the central nervous system (CNS). Alterations of gut microbiota (gut dysbiosis) are frequently observed in MS patients. It is still unknown how gut dysbiosis contributes to development of MS. We report here that gut dysbiosis, which we attribute to expansion of enteric pathogenic bacteria, triggers and/or exacerbates the spontaneous development of experimental autoimmune encephalomyelitis, an animal model of MS. This occurs during the period of young adulthood by reducing development of Foxp3 + Treg cells and expression of E3 ubiquitin ligase genes involved in protection from autoimmune diseases. This study suggests that gut dysbiosis may play a pathological role in the initiation and/or progression of MS during a defined age window.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 16, 2017
- Source ID
- 10.1073/pnas.1615715114
Entities
People
- Ankoor Patel
- John E. Mindur
- Kouichi Ito
- Martin T. Mathay
- Naoko Ito
- Sridhar Boppana
- Sudhir K. Yadav
- Suhayl Dhib-jalbut
Organizations
- Delaware State University
- Harvard Medical School
- National Institute of Allergy and Infectious Diseases
- New Jersey Health Foundation
- Rutgers University
- United States Army Medical Research and Development Command
- University of Washington